calcium
Osteoporosis
Epidemiology
1/3 caucasian women > 64
Risk Factors
Insufficient bone mass at time of skeletal maturity
- peak bone mass is achieved at age 25
Rapid loss of bone after menopause
Low body weight / weight loss / history of smoking / steroids
Primary
Type 1
- postmenopausal
- high turnover / osteoclast mediated
- F x 6
Rickets
Definition
Rickets
- paediatric disorder characterised by deformity and growth retardation
- secondary to defective mineralisation of the growth plate
Osteomalacia
- adult disorder
- defective mineralisation of osteoid
Physiology
Generation of Vit D
Vitamin D3 ingested and absorbed
- activated by sunlight