Mechanism
Elevated tissue oxygen tensions
Assists Neutrophils
- In hypoxic tissue
- require PO2> 40mmHg (5.3Kpa) for bacterial killing
Bacteriocidal to Anaerobes
Potentiates effects of Antibiotics
- Aminoglycosides
- Sulphonamides
- Trimethoprim
- Fluoroquinolones
- and Vancomycin in hypoxic tissues
Indications
Anaerobic fasciitis / Gangrene
- Reduce mortality when added to surgical debridement and Antibiotics
Complex diabetic foot
- reduces amputation rates in complex diabetic foot lesions including osteomyelitis
Crush injury
- shown to improve rate of healing and reduced re-operation in crush injury
Chronic Refractory Osteomyelitis
Technique
Usually use 2-2.8 Atmospheres
Need 6/52 to gain vascular ingrowth