juvenile

Background

Osteochondritis Dissecans

- separation of avascular fragment of bone & cartilage

M : F = 2:1

Mean age 18 years

- can present as young as 9

4:1000

Joint effusion / pain / swelling in two or more joints

- > 6 weeks

- patient > 16 years

Variations

- number of joints affected: oligoarticular (<5) v polyarticular (5 or more)

- rheumatoid factor positive or negative

- systematic symptoms (rash / fever / lympadenopathy / organomegaly)

1:10,000

Familial clusters

HLA-gene associations