Malignant cartilage producing tumour
20% of primary bone tumours
3rd most common
- 1 in 500 000
Relatively non-aggressive / usually Grade I
Average age 40
Male > Females
Arises de novo
Benign lesion with a wide spectrum of behavior characterized by stromal cells and giant cells
Common
- 20% of benign tumours
More common females
- F:M = 1.5:1
- most tumours M>F
Usually patient in 20's
- usually after skeletal maturity
- 3% < epiphyseal closure
Degenerative arthropathy due to Alkaptonuria
Rare hereditary disorder of tyrosine and phenylalanine breakdown
Homogentisic acid enzyme deficiency
- accumulate Homogentisic Acid
- product of tyrosine breakdown
Homogentisic acid deposited in cartilage & other soft tissues
- polymerises
80% cancer patients have spinal metastasis at autopsy
Spine is number one site for bony metastasis (50%)
Hexagon: PBBLTK
Prostate Breast