hypercalcaemia

Hypercalcaemia

Definition

 

> 10 mg / dl

- must be corrected for albumin

 

Causes

 

Malignancy

- multiple myeloma / lung cancer / breast cancer

 

Hyperparathyroidism

- elevated PTH

 

Issue

 

High mortality associated with hypercalcaemia of malignancy

 

Physiology

 

40% albumin bound

50% ionised and active