femoral head avn

Sickle Cell Disease

Epidemiology

 

Black population

- heterozygote protective from malaria

- AD

 

Pathogenesis

 

Abnormal peptide substitution in ß chain of Hb

- HbS

 

Homozygous 1%

- HbSS

- sickling occurs with relative hypoxia

- trapped in blood vessels

- necrosis & pain

 

Heterozygous 8%

- sickle cell trait

- Hb SA

THR Resurfacing

ConceptBirmingham Hip Resurfacing

 

Femur

- removal of femoral head cartilage

- resurfacing with metal

- cemented / uncemented

 

Acetabulum

- standard technique

 

Bearing surface

- metal on metal

 

Indications

 

Relatively young man (40 - 50)

OA